1、at the end of 意为“在……末，在……尽头”，既可以表示时间的概念也可以表示空间的概念。

2、而in the end只能表示时间的概念,其后不能接of短语，相当于finally, at last. (1) At the end of this term we will have a final examination. (2) He died in the end though the doctors tried their best. (3) There is a hospital at the end of this road. the end of是.的终结的意思,比如 the end of day。