lose hope; beyond hope；disappointed；let down。

例句：

用作名词 (n.)

1、Not getting an invitation to the party is a big letdown for Jill.

没有接到参加晚会的邀请，吉尔感到十分失望。

2、To some, the apparent limitations of quantum computers might come as a letdown.

或许会有些人认为，量子电脑明显的局限真是令人失望。

3、医生们对他的痊愈失望了。The doctors could hold out no hope of his recovery.

4、你本应该接受那个的，我对你很失望。You should have accepted that. I'm disappointed in you.

5、我会努力工作，我不想让他失望。I'll work hard. I don't want to let him down

6、我们清楚明白地表达了我们的失望、伤心和愤怒。We expressed in the clearest possible way our disappointment, hurt and anger

7、我们等了21年了，如今不要让我们失望。We waited twenty-one years, don't fail us now.

8、这是她靠前次感受到失望。This is the first time she has experienced disappointment

9、我们觉得已经受够了失望和情绪困扰。We feel that we have had our fill of disappointments and emotional upsets.

10、你做那样的事使我太失望了。You let me down doing a thing like that.

11、出问题时，我们大家自然都感到失望和沮丧。When things go wrong, all of us naturally feel disappointed and frustrated

12、现在可以回答你的问题了，你母亲失望的原因就在这里。And so, to answer your question, that's why your mother is disappointed

13、我对已发生的一切感到极其失望。I feel absolutely dreadful about what has happened.

词义辨析

despair，desperation，depression，disappointment

这些名词都有“绝望、沮丧”之意。

1、despair普通用词，指因灾难等因素而丧失希望和信心，陷入沮丧，绝望的境地。

2、desperation语气强烈，指因绝望而使人采取无所顾忌的疯狂行动。

3、depression侧重指因遭受重大失利或挫折而产生的低落情绪。

4、disappointment多指愿望或期望的落空。