区别举例：含义不同、强调重点不同、用法不同。talk to中文翻译为“和某人交谈”、“向…谈”，介词to表示方向，强调告诉某人什么事；talk with含义为“与…谈话”，即双方都要发表言论,相互沟通。

一、talk to的含义及双语例句

talk to意为和某人交谈;向…谈;〔口语〕申斥。例句有：

1、I'd like to talk to you about a personal matter.

我想和你谈点私事。

2、Have I picked a bad time to talk to you?

我是不是挑了个不恰当的时间跟你谈话？

3、I made a mental note to talk to her about it.

我记着要去和她谈谈这事儿。

4、It would be better for him to talk to his parents about his problems.

他把自己的问题同父母谈谈会比较好。

5、He found it difficult to talk to members of the opposite sex.

他觉得很难与异***谈。

6、How dare you talk to me like that?

你竟敢这样对我说话？

二、talk with的含义及双语例句

talk with意为与……谈话。例句有：

1、It is bad manners to talk with your mouth full.

嘴里塞满了东西跟人说话是不礼貌的。

2、I had a long talk with my boss about my career prospects.

我和老板就我的事业前景进行了一次长谈。

3、I had to have a heart-to-heart talk with her.

我得推心置腹地和她谈一谈。

4、It was really a gas to find someone I could talk with.

找到一个能和我谈得来的人真是一件让人高兴的事。

5、I've been wanting to have a little talk with you.

我一直想找机会跟你谈几句。