区别就是它们意思是不一样具体的不同如下

be tired of中文意思是v.

厌烦;厌倦;

例句

I know that you must be tired of this excuse.

be tired with中文意思是因……而劳累;

例句

You may be tired with reading, but you should not be tired of it.

看书可能使你疲劳，但不应该对看书感到厌烦。

be tired out中文意思是

筋疲力尽;。